UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors
Abstract The Retinoic acid-Inducible Gene I (RIG-I) like receptors (RLRs) are the major viral RNA sensors essential for the initiation of antiviral immune responses.RLRs are subjected to stringent transcriptional and posttranslational regulations, of which ubiquitination is one of the most important.However, the role of ubiquitination in RLR transc